Principal Investigators //
- David Bridwell, PhD >
- Vince Calhoun, PhD >
- Arvind Caprihan, PhD >
- Zikuan Chen, PhD >
- Vince Clark, PhD >
- Eric D. Claus, PhD
- Carla Harenski, PhD >
- Kent Hutchison, PhD >
- Kent A. Kiehl, PhD >
- Jeffrey D. Lewine, PhD >
- Jingyu Liu, PhD >
- Andrew R. Mayer, PhD >
- John Phillips, MD >
- Sergey Plis, PhD >
- Matthew Shane, PhD >
- Julia M. Stephen, PhD >
- Jing Sui, PhD >
- Jessica Turner, PhD >
- Qingbao Yu, PhD >
Eric D. Claus, PhD
Assistant Professor of Translational Neuroscience
Dr. Claus focuses on addiction research, with an emphasis on the cognitive neuroscience and genetics of alcohol and nicotine dependence. His research aims to understand the cognitive and motivational mechanisms by which addictive disorders emerge and how the brain changes over time with increased exposure to drugs of abuse. In addition, his research uses intravenous alcohol administration to better understand how cognitive functioning is impaired when individuals are intoxicated and how these impairments may lead to increased risk for developing alcohol dependence.
Dr. Claus is also interested in developing neuromodulatory approaches such as brain stimulation and real-time fMRI to supplement currently available treatments for substance dependence.
Selected Publications //
- Default mode network deactivation to smoking cue relative to food cue predicts treatment outcome… >
- Alterations of Resting State Functional Network Connectivity in the Brain of Nicotine and Alcohol… >
- Neuroimaging measures of error-processing: Extracting reliable signals from event-related… >
- Multimodal imaging measures predict rearrest >
- CREB-BDNF pathway influences alcohol cue-elicited activation in drinkers >
- Dose Specific Effects of Olanzapine in the Treatment of Alcohol Dependence >
- Moderating effect of working memory capacity on acute alcohol effects on BOLD response during….... >
- Dose-dependent effects of intravenous alcohol administration on cerebral blood flow in young adults >
- A large scale (N=102) functional neuroimaging study of error processing in a Go/NoGo task >
- Neural Mechanisms of Risk Taking and Relationships with Hazardous Drinking >
- Negative reinforcement learning is affected in substance dependence. >
- Cognitive control reflects context monitoring, not motoric stopping, in response inhibition. >
- Effect of homozygous deletions at 22q13.1 on alcohol dependence severity and cue-elicited BOLD… >
- Identifying Neurobiological Phenotypes Associated with Alcohol Use Disorder Severity >
- Neural and Behavioral Mechanisms of Impulsive Choice in Alcohol Use Disorder. Alcoholism: Clinical >
Effects of Chronic Alcohol Use on Neurocognitive Function
Chronic alcohol use is known to affect the structural integrity of the brain, which is believed to contribute to poor cognitive functioning and may lead to worse treatment outcomes. The goal of this area of research is to identify the key changes that occur both the behavioral and neural levels as a result of chronic alcohol use. Once these changes are identified, it may be possible to use neuromodulation techniques to improve functioning in damaged regions in order to supplement current treatment approaches.
Sensitivity to Intravenous Ethanol
This project aims to identify neural, psychophysiological, and behavioral markers of alcohol sensitivity, and to understand the relationships between these measures and those obtained through questionnaire-based self-reports. In order to understand these relationships, we will use intravenous infusion of ethanol to achieve and maintain a constant breath alcohol concentration in participants while they complete tasks of response inhibition and cue reactivity while undergoing fMRI. The findings from this project will help to refine the endophenotype of alcohol sensitivity for use in future studies that investigate the genetic basis of sensitivity.
